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Rahim et al. show that immune checkpoint blockade activates CD8 T cell differentiation and proliferation in the lymph node, not within the tumor microenvironment, and these cells can be detected in transit via blood profiling.
A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity - ScienceDirect
Lymph Node Delivery Strategy Enables the Activation of Cytotoxic T Lymphocytes and Natural Killer Cells to Augment Cancer Immunotherapy
Dynamics and specificities of T cells in cancer immunotherapy
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes - ScienceDirect
Whole-body CD8+ T cell visualization before and during cancer immunotherapy: a phase 1/2 trial
Frontiers The Emerging Interplay Between Recirculating and Tissue-Resident Memory T Cells in Cancer Immunity: Lessons Learned From PD-1/PD-L1 Blockade Therapy and Remaining Gaps
Cytotoxic CD8+ T cells in cancer and cancer immunotherapy
Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis: Trends in Immunology
Cancers, Free Full-Text
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes - ScienceDirect
Frontiers Targeting the immune microenvironment for ovarian cancer therapy
// Powered by Mass Cytometry - Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes
Targeting tumor extracellular matrix activates the tumor-draining lymph nodes
Targeting the epigenome to reinvigorate T cells for cancer immunotherapy, Military Medical Research